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KMID : 0369819930230040187
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 4 p.187 ~ p.206
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Conjugation of Protein and Peptide Drugs with Hydrophilic Polymers and Thier Applications
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용철순/Yong CS
손영택/Sohn YT
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Abstract
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Since the advent of recombinant DNA technology coupled with other biotechnology a variety of therapeutically effective proteins and peptides have been extensively invesitigated and many of them are now on clinical trial. They, however, suffer from some problems such as immunogenicity, antigenicity, instability and short half-life in circulation due to their proteinous natures. These drawbacks can be overcome successfully by conjugating proteins and peptides with hydrophilic polymers such as polyethylene glycol (PEG), albumin or dextran. The resulting soluble conjugates showed reduced antigenicity and immunogenicity, increased circulatory half-life, enhanced stability against proteolytic degradation. Comparing with the unmodified proteins and peptides, the therapeutic potential of conjugates is greatly enhanced. Clinical applications of these conjugates have shown promising results for the future use.
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KEYWORD
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Protein-polymer conjugate, Polyethylene glycol, Dextran, Stability, Half-life, Immunogenicity
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